Optical structural imaging
We are a research lab developing new optical tools to fingerprint the structure of single molecules in biological samples, to bridge atomic scale structural imaging, protein profiling, and human scale clinical diagnosis. We use these tools to advance research into the molecular and structural mechanisms of neurodegeneration.
We publish across a wide range of topics, from single-molecule and super-resolution microscopy to cell biology and neurodegeneration. For a comprehensive list of publications, visit our
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PloS Biology
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease
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Nature Communications
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-ß in Alzheimer’s disease
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Angewandte Chemie
Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer's Disease-Relevant Tau Aggregates in Human Samples
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Nature Protocols
Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging
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Molecular Cell
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
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Nature Methods
Quantitative analysis of super-resolved structures using ASAP
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PNAS
Dynamic label-free imaging of lipid nanodomains
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Team
We are a multi-disciplinary team of physicists, chemists, engineers, and software developers working together to develop new single-molecule instrumentation, software, and assays to rewire structural biology and diagnostics to decode dementia and other complex biological processes.
John Danial
Principal Investigator
Lecturer in experimental biophotonics
DPhil in Physical Chemistry, Oxford
PDRA with Sir David Klenerman FRS, Cambridge and Ana Garcia-Saez, Tübingen
Keer Feng
PhD student, Chemistry
MSc in Chemistry, Warwick
Ava Kelly
MSc student, Theoretical Physics
MSc in Theoretical Physics, St Andrews
Stuart van Breda
MSc student, Physics
MSc in Physics, St Andrews
Siqi Liu
Software developer
MSc in Game Development, Abertay
BSc in Computer Science, St Andrews
Sabrina Keating
Alumna
PhD student with Jeremy Baumbery FRS, Cambridge
BSc in Physics, St Andrews
Our work is multi-disciplinary, and so is our funding. We are grateful to our funders who are investing in the development of cutting-edge technologies and their application to some of the toughest biological and health problems.
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